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|
Publications:
| 1. |
Stereochemistry
of capsorubin and synthesis of its optically inactive epimers.
R. D. G. Cooper, L. M. Jackman, and B. C. L. Weedon, Proc.
Chem. Soc., 215 (1962). |
| 2. |
Carotenoids
and related compounds. X. Synthesis of renieratene, isorenieratene,
renierapurpurin, and other arylpolyenes. R. D. G. Cooper,
J. B. Davis, and B. C. L. Weedon, J. Chem. Soc., 41, 5637
(1963). |
| 3. |
The
structure of kryptocapsin. L. Cholnoky, J. Szabolcs. R. D.
G. Cooper and B. C. L. Weedon, Tetrahedron Lett., 1257 (1963). |
| 4. |
The
structure of hydrocyansalide, a new reagent for magnesium.
J. E. Baldwin, D. J. Blythin, R. D. G. Cooper, R. Smith, and
E. S. Waight, Chem. Commun., 709 (1967). |
| 5. |
Structural
studies on penicillin derivatives. I. Configuration of phenoxymethylpenicillin
sulfoxide. R. D. G. Cooper, P. V. Demarco, J. C. Cheng, and
N. D. Jones, J. Am. Chem. Soc., 91, 1408 (1969). |
| 6. |
Structural
studies on penicillin derivatives. II. Configuration of epiphthalimidopenicillin
sulfoxides. R. D. G. Cooper, P. V. Demarco, and D. O. Spry,
J. Am. Chem. Soc., 91, 1528 (1969). |
| 7. |
Structural
studies on penicillin derivatives. III. Rearrangement and
fragmentation of penicillin V. S. Kukolja, R. D. G. Cooper,
and R. B. Morin, Tetrahedron Lett., 3381 (1969). |
| 8. |
Structural
studies on penicillin derivatives. IV. Novel rearrangement
of penicillin V sulfoxide. R. D. G. Cooper, and F. L. Jose,
J. Am. Chem. Soc., 92, 2575 (1970). |
| 9. |
Structural
studies on penicillin derivatives. V. Penicillin sulfoxide-sulfenic
acid equilibrium. R. D. G. Cooper, J. Am. Chem. Soc., 92,
5010 (1970). |
| 10. |
Structural
studies on penicillin derivatives: carbon-13 nuclear magnetic
resonance studies of some penicillins and related sulfoxides.
R. A. Archer, R. D. G. Cooper, P. V. Demarco, and L. F. Johnson,
J. Chem. Soc., D, 1291 (1970). |
| 11.
|
Chemistry
of cephalosporin antibiotics. XVI. Configurational and conformational
analysis of deacetoxy-?2- and -?3- cephalosporins and their
corresponding sulfoxide isomers by nuclear magnetic resonance.
R. D. G. Cooper, P. V. Demarco, C. F. Murphy, and L. A. Spangle,
J. Chem. Soc., C, 340 (1970). |
| 12. |
Chemistry
of cephalosporin antibiotics. XIX. Transformation of ?2-cephem
to ?3-cephem by oxidation-reduction at sulfur. G. V. Kaiser,
R. D. G. Cooper, R. E. Koehler, C. F. Murphy, J. A. Webber,
I. G. Wright, and E. M. Van Heyningen, J. Org. Chem., 35,
2430 (1970). |
| 13. |
Structural
studies on penicillin derivatives. VII. Rearrangement of penicillin
sulfoxides with trimethyl phosphite-acetic anhydride. L. D.
Hatfield, J. Fisher, F. L. Jose, and R. D. G. Cooper, Tetrahedron
Lett., 4897 (1970). |
| 14. |
Chemistry
of cephalosporin antibiotics. XXI. Conversion of penicillins
to cephalexin. R. R. Chauvette, P. A. Pennington, C. W. Ryan,
R. D. G. Cooper, F. L. Jose, I. G. Wright, E. M. Van Heyningen,
and G. W. Huffman, J. Org. Chem., 36, 1259 (1971). |
| 15. |
Determination
of stereochemistry and reactions of 1-hydroxy-3-methyl-cephalosporins.
G. E. Gutowski, C. M. Daniels, and R. D. G. Cooper, Tetrahedron
Lett., 3429 (1971). |
| 16. |
Structural
studies on penicillin derivatives. VIII. Possible model biosynthetic
route to penams and cephems. R. D. G. Cooper, J. Am. Chem.
Soc., 94, 1018 (1972). |
| 17. |
Structural
studies on penicillin derivatives. IX. Synthesis of thiazolidineazetidinones.
R. D. G. Cooper and F. L. Jose, J. Am. Chem. Soc., 94, 1021
(1972). |
| 18. |
Direct
6-methoxylation of penicillin derivatives. Convenient pathway
to substituted ß-lactam antibiotics. J. E. Baldwin,
F. J. Urban, R. D. G. Cooper, and F. L. Jose, J. Am. Chem.
Soc., 95, 2401 (1973). |
| 19. |
Chemical
Interconversion of the ß-lactam antibiotics. R. D. G.
Cooper, L. D. Hatfield, and D. O. Spry, Accounts Chem. Res.,
6, 32 (1973). |
| 20. |
Carotenoids
and related compounds. XXXII. Synthesis of astaxanthin, phoenicoxanthin,
hydroxyechinenone and the corresponding diosphenols. R. D.
G. Cooper, J. B. Davis, A. P. Leftwick, C. Price, and B. C.
L. Weedon, J. Chem. Soc., Perkin Trans., 1, 2195 (1975). |
| 21. |
Total
synthesis of nocardicin A. Synthesis of 3-ANA. G. A. Koppel,
L. McShane, F. Jose, and R. D. G. Cooper, J. Am. Chem. Soc.,
100, 3933 (1978). |
| 22. |
A
chiral synthesis of D-homoserine and its application to the
synthesis of nocardicin A. R. D. G. Cooper, F. Jose, L. McShane,
and G. A. Koppel, Tetrahedron Lett., 2243 (1978). |
| 23. |
Chlorination
of azetidinone derivatives. R. D. G. Cooper, Tetrahedron Lett.,
781 (1980). |
| 24. |
Chiral
synthesis of protected 3-amino-4-alkoxycarbonyl-2-azetidinones
from ß-hydroxy aspartic acid. P. G. Mattingly, M. J.
Miller, R. D. G. Cooper, and B. W. Dougherty, J. Org. Chem.,
48, 3536 (1983). |
| 25. |
Stereochemistry
and synthesis of capsorubin. R. D. Bowden, R. D. G. Cooper,
C. J. Harris, G. P. Moss, B. C. L. Weedon, and L. M. Jackman,
J. Chem. Soc. Trans I, 1465 (1983). |
| 26. |
Orally
absorbable cephalosporin antibiotics. I. Structure-activity
relationships of benzothienyl and napthylglycine derivatives
of 7-aminodeacetoxycephalosporanic acid. S. Kujolja, S. E.
Draheim, J. L. Pfeil, R. D. G. Cooper, B. J. Graves, R. E.
Holmes, D. A. Neel, G. W. Huffman, J. A. Webber, M. D. Kinnick,
R. T. Vasileff, and B. J. Foster, J. Med. Chem., 28, 1886
(1985). |
| 27. |
Chiral
control of the Staudinger reaction. R. D. G. Cooper, B. W.
Daugherty and D. B. Boyd, Pure and Applied Chem., 59, 485
(1987). |
| 28. |
Orally
absorbable Cephalosporin Antibiotics. 2. Structure-Activity
Studies of Bicyclic Glycine Derivatives of 7-Aminodeacetoxycephalosporanic
Acid. S. Kukolja, S. E. Draheim, B. J. Graves, D. C. Hunden,
J. L. Pfeil, R. D. G. Cooper, J. L. Ott, and F. T. Counter,
J. Med. Chem., 28, 1896 (1985). |
| 29. |
An
improved process for the preparation of oxazolinoazetidinones
and 1-oxadethiacephems from exomethylene cephem sulfoxides.
R. D. G. Cooper, M. D. Kinnick, L. R. Peters, and J. M Morin,
Jr., Syn. Comm., 18, 763 (1988). |
| 30. |
The
Role of Sulphur in Cephalosporin Biosynthesis. J.E.Baldwin,
K.C.Goh , M.E.Wood , C.J.Schofield , G.W.Huffman and R.D.G.Cooper
.Bioorganic and Medicinal Chemistry Letters ,1,421,(1991). |
| 31. |
The
Carbacephems;A New Beta-Lactam Class. R.D.G.Cooper, The American
Journal of Medicine, 92, 2, 1992. |
| 32. |
The
Enzymes Involved in the Biosynthesis of Penicillin and Cephalosporin;
Their Structure and Function. R.D.G.Cooper , Bioorganic &
Medicinal Chemistry, 1,1,(1993). |
| 33. |
b-Lactamase
Inhibitors Derived from N-Tosyl-b-Lactams. M.T.Teng, M.J.Miller,
T.I.Nicas, J.Grissom-Arnold, & R.D.G.Cooper, Bioorganic
& Medicinal Chemistry, 1,151, (1993). |
| 34. |
The
Carbacephems. R.D.G. Cooper & D.A.Preston. New Investigational
Drugs;
3, 831, 1994. |
| 35. |
Synthesis
and Biological Evaluation of 6-Azabicyclo[3.2.0]hept-2-ene
Derivatives as Potential Anti-bacterial Agents and b-lactamase
Inhibitors. Rajender Singh & R.D.G.Cooper, Tetrahedron,
50,12049, 1994. |
| 36. |
Activity
of the Semisynthetic Glycopeptide LY 191145 against Vancomycin-resistant
Enterococci and other Gram-Positive Bacteria. T.I.Nicas, D.L.Mullen,
J.E.Flokowitsch, D.A.Preston, N.J.Snyder, R.E.Stafford and
R.D.G.Cooper. Antimicrobial Agents and Chemotherapy, 39, 2585,
1995.. |
| 37. |
Reductive
Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial
Activity. Robin.D.G.Cooper, Nancy.N.Snyder, Mark.J.Zweifel,
Michael.A.Staszak, Stephen.C.Wilkie, Thalia.I.Nicas, DeborahL.Mullen,
Thomas.F.Butler, Michael.J.Rodriguez, Brett.E.Huff, and Richard.C.Thompson.
J.Antibiotics, 49, 575, 1996. |
| 38. |
Semisynthetic
Glycopeptide Antibiotics Derived from LY 264826 active against
Vancomycin-resistant Enterococci. T.I.Nicas, D. L.Mullen,
J.E.Flokowitsch, D.A.Preston, N.J.Snyder, M.J.Zweifel, S.C.Wilkie,
M.J.Rodriguez, R.C.Thompson,and R.D.G.Cooper. Antimicrobial
Agents and Chemotherapy, 40, 2194, 1996. |
| 39. |
Design
and Sythesis of an Azetidinone-Based Peptide Combinatorial
Library. D.C.Hunden, R.F.Bruns, M.O.Chaney, R.D.G. Cooper,
J.J.Skelton, and G.A.Koppel. Bioorganic and Medical Chemistry
Letters , In Press |
| 40. |
Semisynthetic
Glycopeptide Derivatives, R.D.G. Cooper and R.C.Thompson.
Annual Reports in Medicinal Chemistry, Vol. 31, 131,1996 |
| 41. |
Novel
Glycopeptide Antibiotics: N-Alkylated Derivatives Active against
Vancomycin-Resistant Enterococci. M.J.Rodriguez, N.J.Snyder,
M.J.Zweifel, S.C. Wilkie, D.R.Stack, R.D.G.Cooper, T.A.Nicas,
D.L.Mullin, T.F.Butler, and R.C.Thompson. J. Antibiotics,
51, 560, 1998. |
| 42. |
Enzymatic
Deacylation of Teichplanin Followed by Reductive Alkylation:
Synthesis and Antibiotic Activity of New Glycopeptides. N.J.Snyder,
R.D.G.Cooper, B.S.Briggs, M.Zmijewski, D.L.Mullen, R.E.Kaiser
and T.I.Nicas. J. Antibiotics, 51, 945, 1998. |
Book
Chapters:
| 1. |
Rearrangements
of cephalosporins and penicillins. R. D. G. Cooper and D.
O. Spry, in "Penicillins and Cephalosporins: Chemistry
and Biology," (E. H. Flynn, ed.). Academic Press, New
York, 1972, pp. 183-254. |
| 2. |
Penicillins
and Cephalosporins. R. D. G. Cooper, in "MTP International
Review of Science," (D. H. Hey, ed.), Vol. 6. Butterworth
Press, 1973, pp. 247-282. |
| 3. |
New
ß-lactam antibiotics. R. D. G. Cooper, in "Topics
in Antibiotic Chemistry," (P. Sammes, ed.), Vol. 3. Ellis
Horwood, 1980, pp. 39-199. |
| 4. |
Chemistry
of penicillin sulfoxide. R. D. G. Cooper and G. A. Koppel,
in "Chemistry and Biology of ß-lactam Antibiotics"
(R. B. Morin and M. Gorman, eds.), Vol. I. Academic Press,
New York, 1982, pp. 2-92. |
| 5. |
The
Carbacephems . R.D.G.Cooper, in "The Chemistry of Beta-Lactams"
Ed. M.Page, Blackie &Son Ltd, London, 1992. |
| 6. |
Vancomycin
and other Glycopeptides. T.I.Nicas & R.D.G.Cooper, in
"Biology of Industrial Antibiotics", Ed. W.Strohl,
Elsevier Press, 1995 In Press. |
| 7. |
Semisynthetic
Glycopeptide Antibiotics. R.D.G. Cooper and R.C.Thompson,
in Annual Reports in Medicinal Chemistry, Academic Press,
1996, 31, 131. |
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